1) "Primary systemic treatment and concomitant low dose radiotherapy for breast cancer: Final results of a prospective phase II study", Nardone L, et al., The Breast (2014), http://dx.doi.org/10.1016/j.breast.2014.06.005
2) "Tumor Regression Grading in Rectal Cancer: Is It Time To Move Forward?" V. Valentini, B. D. Minsky - JCO, April 21, 2014"
3) "Clinical management of gastroesophageal junction tumors: past and recent evidences for the role of radiotherapy in the multidisciplinary approach" Cellini et al., Radiation Oncology 2014, 9:45
4) Bussu F, Mura F, Francesco M, Bertino G, Occhini A, Almadori G, Galli J, Pandolfini M, Gallus R, Autorino R, Guidi ML, Dinapoli N, Valentini V, Paludetti G, Benazzo M. Oncological outcome of hypopharyngeal carcinoma treated with different modalities at two different university hospitals. Head Neck. 2014 Dec 9. doi: 10.1002/hed.23938. [Epub ahead of print] PubMed PMID: 25491424.
5) De Felice F, Musio D, Terenzi V, Valentini V, Cassoni A, Tombolini M, De Vincentiis M, Tombolini V. Treatment improvement and better patient care: which is the most important one in oral cavity cancer? Radiat Oncol. 2014 Nov 27;9(1):263. [Epub ahead of print] PubMed PMID: 25479896; PubMed Central PMCID: PMC4263000.
6) van Stiphout RG, Valentini V, Buijsen J, Lammering G, Meldolesi E, van Soest J, Leccisotti L, Giordano A, Gambacorta MA, Dekker A, Lambin P. Nomogram predicting response after chemoradiotherapy in rectal cancer using sequential PETCT imaging: A multicentric prospective study with external validation. Radiother Oncol. 2014 Nov;113(2):215-22. doi: 10.1016/j.radonc.2014.11.002. Epub 2014 Nov 20. PubMed PMID: 25466368.
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8) van den Broek CB, van Gijn W, Bastiaannet E, Møller B, Johansson R, Elferink MA, Wibe A, Påhlman L, Iversen LH, Penninckx F, Valentini V, van de Velde CJ; EURECCA Consortium. Differences in pre-operative treatment for rectal cancer between Norway, Sweden, Denmark, Belgium and the Netherlands. Eur J Surg Oncol. 2014 Dec;40(12):1789-96. doi: 10.1016/j.ejso.2014.09.011. Epub 2014 Oct 18. PubMed PMID: 25454831.
9) Sainato A, Cernusco Luna Nunzia V, Valentini V, De Paoli A, Maurizi ER, Lupattelli M, Aristei C, Vidali C, Conti M, Galardi A, Ponticelli P, Friso ML, Iannone T, Osti FM, Manfredi B, Coppola M, Orlandini C, Cionini L. No benefit of adjuvant Fluorouracil Leucovorin chemotherapy after neoadjuvant chemoradiotherapy in locally advanced cancer of the rectum (LARC): Long term results of a randomized trial (I-CNR-RT). Radiother Oncol. 2014 Nov;113(2):223-9. doi: 10.1016/j.radonc.2014.10.006. Epub 2014 Nov 14. PubMed PMID: 25454175.
10) Maas M, Nelemans PJ, Valentini V, Crane CH, Capirci C, Rödel C, Nash GM, Kuo LJ, Glynne-Jones R, García-Aguilar J, Suárez J, Calvo FA, Pucciarelli S, Biondo S, Theodoropoulos G, Lambregts DM, Beets-Tan RG, Beets GL. Adjuvant chemotherapy in rectal cancer: Defining subgroups who may benefit after neoadjuvant chemoradiation and resection: A pooled analysis of 3,313 patients. Int J Cancer. 2014 Nov 22. doi: 10.1002/ijc.29355. [Epub ahead of print] PubMed PMID: 25418551.
11) Valentini V, Boldrini L, Damiani A, Muren LP. Recommendations on how to establish evidence from auto-segmentation software in radiotherapy. Radiother Oncol. 2014 Sep;112(3):317-20. doi: 10.1016/j.radonc.2014.09.014. Epub 2014 Oct 11. PubMed PMID: 25315862.
12) Morganti AG, Falconi M, van Stiphout RG, Mattiucci GC, Alfieri S, Calvo FA, Dubois JB, Fastner G, Herman JM, Maidment BW 3rd, Miller RC, Regine WF, Reni M, Sharma NK, Ippolito E, Valentini V. Multi-institutional Pooled Analysis on Adjuvant Chemoradiation in Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):911-7. doi: 10.1016/j.ijrobp.2014.07.024. Epub 2014 Sep 11. PubMed PMID: 25220717.
13) Macchia G, Deodato F, Cilla S, Torre G, Corrado G, Legge F, Gambacorta MA, Tagliaferri L, Mignogna S, Scambia G, Valentini V, Morganti AG, Ferrandina G. Volumetric intensity modulated arc therapy for stereotactic body radiosurgery in oligometastatic breast and gynecological cancers: feasibility and clinical results. Oncol Rep. 2014 Nov;32(5):2237-43. doi: 10.3892/or.2014.3412. Epub 2014 Aug 18. PubMed PMID: 25175950.
14) Deodato F, Cilla S, Macchia G, Torre G, Caravatta L, Mariano G, Mignogna S, Ferro M, Mattiucci GC, Balducci M, Frascino V, Piermattei A, Ferrandina G, Valentini V, Morganti AG. Stereotactic Radiosurgery (SRS) with Volumetric Modulated Arc Therapy (VMAT): Interim Results of a Multi-arm Phase I Trial (DESTROY-2). Clin Oncol (R Coll Radiol). 2014 Dec;26(12):748-56. doi: 10.1016/j.clon.2014.08.005. Epub 2014 Aug 29. PubMed PMID: 25175042.
15) Minsky BD, Valentini V. MRI-based treatment decision making for rectal cancer. Oncology (WillistonPark). 2014 Aug;28(8):680-1. PubMed PMID: 25140624.
16) Mantini G, Fersino S, Alitto AR, Frascino V, Massaccesi M, Fionda B, Iorio V, Luzi S, Balducci M, Mattiucci GC, Di Nardo F, De Belvis A, Morganti AG, Valentini V. Intensified adjuvant treatment of prostate carcinoma: feasibility analysis of a phase I/II trial. Biomed Res Int. 2014;2014:480725. doi: 10.1155/2014/480725. Epub 2014 Jun 30. PubMed PMID: 25093169; PubMed Central PMCID: PMC4100352.
17) Eriksen JG, Salembier C, Rivera S, De Bari B, Berger D, Mantello G, Müller AC, Martin AN, Pasini D, Tanderup K, Palmu M, Verfaillie C, Pötter R, Valentini V; ESTRO. Four years with FALCON - an ESTRO educational project: achievements and perspectives. Radiother Oncol. 2014 Jul;112(1):145-9. doi: 10.1016/j.radonc.2014.06.017. Epub 2014 Jul 25. PubMed PMID: 25070586.
18) Bussu F, Sali M, Gallus R, Petrone G, Zannoni GF, Autorino R, Dinapoli N, Santangelo R, Vellone VG, Graziani C, Miccichè F, Almadori G, Galli J, Delogu G, Sanguinetti M, Rindi G, Tommasino M, Valentini V, Paludetti G. Human papillomavirus (HPV) infection in squamous cell carcinomas arising from the oropharynx: detection of HPV DNA and p16 immunohistochemistry as diagnostic and prognostic indicators--a pilot study. Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):1115-20. doi: 10.1016/j.ijrobp.2014.04.044. Epub 2014 Jul 8. PubMed PMID: 25035216.
19) Valentini V, Abrahamsson PA, Aranda SK, Astier A, Audisio RA, Boniol M, Bonomo L, Brunelli A, Bultz B, Chiti A, De Lorenzo F, Eriksen JG, Goh V, Gospodarowicz MK, Grassi L, Kelly J, Kortmann RD, Kutluk T, Plate A, Poston G, Saarto T, Soffietti R, Torresin A, van Harten WH, Verzijlbergen JF, von Kalle C, Poortmans P. Still a long way to go to achieve multidisciplinarity for the benefit of patients: commentary on the ESMO position paper (Annals of Oncology 25(1): 9-15, 2014). Ann Oncol. 2014 Sep;25(9):1863-5. doi: 10.1093/annonc/mdu245. Epub 2014 Jul 10. PubMed PMID: 25015332.
20) Valentini V, Cellini F. New perspectives in treatment decision for integrated management of rectal cancer: multimodal research for multimodal treatments. G Chir. 2014 May-Jun;35(5-6):113-6. PubMed PMID: 24979100.
21) Broggi S, Scalco E, Fiorino C, Belli ML, Sanguineti G, Ricchetti F, Dell'Oca I, Dinapoli N, Valentini V, Di Muzio N, Cattaneo GM, Rizzo G. The Shape of Parotid DVH Predicts the Entity of Gland Deformation During IMRT for Head and Neck Cancers. Technol Cancer Res Treat. 2014 Jun 16. [Epub ahead of print] PubMed PMID: 24945374.
22) Cellini F, Morganti AG, Genovesi D, Silvestris N, Valentini V. Role of microRNA in response to ionizing radiations: evidences and potential impact on clinical practice for radiotherapy. Molecules. 2014 Apr 24;19(4):5379-401. doi: 10.3390/molecules19045379. PubMed PMID: 24879584.
23) Fidanzio A, Porcelli A, Azario L, Greco F, Cilla S, Grusio M, Balducci M, Valentini V, Piermattei A. Quasi real time in vivo dosimetry for VMAT. Med Phys. 2014 Jun;41(6):062103. doi: 10.1118/1.4875685. PubMed PMID: 24877830.
24) Boelens PG, Taylor C, Henning G, Marang-van de Mheen PJ, Espin E, Wiggers T, Gore-Booth J, Moss B, Valentini V, van de Velde CJ. Involving patients in a multidisciplinary European consensus process and in the development of a 'patient summary of the consensus document for colon and rectal cancer care'. Patient. 2014;7(3):261-70. doi: 10.1007/s40271-014-0061-4. PubMed PMID: 24862378.
25) Meldolesi E, van Soest J, Dinapoli N, Dekker A, Damiani A, Gambacorta MA, Valentini V. An umbrella protocol for standardized data collection (SDC) in rectal cancer: a prospective uniform naming and procedure convention to support personalized medicine. Radiother Oncol. 2014 Jul;112(1):59-62. doi: 10.1016/j.radonc.2014.04.008. Epub 2014 May 19. PubMed PMID: 24853366.
26) Ricci F, Paradisi A, Silveri SL, Sampogna F, Miccichè F, Bonomo PL, DiNapoli N, Valentini V, Capizzi R, Guerriero C. Adverse skin reactions during treatment with cetuximab plus radiotherapy: Multidisciplinary approach to minimize radio-chemotherapy interruption. J Dermatolog Treat. 2014 Jun 17:1-5. [Epub ahead of print] PubMed PMID: 24852820.
27) Pucciarelli S, Valentini V, De Paoli A, Maretto I. The authors reply. Dis Colon Rectum. 2014 Jun;57(6):e360-1. doi: 10.1097/DCR.0000000000000132. PubMed PMID: 24807611.
28) Belli ML, Scalco E, Sanguineti G, Fiorino C, Broggi S, Dinapoli N, Ricchetti F, Valentini V, Rizzo G, Cattaneo GM. Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia. Strahlenther Onkol. 2014 Oct;190(11):1001-7. doi: 10.1007/s00066-014-0669-2. Epub 2014 Apr 23. PubMed PMID: 24756139.
29) Gennaro P, Della Monaca M, Aboh IV, Priore P, Facchini A, Valentini V. "Naked microvascular bone flap" in oral reconstruction. Ann Plast Surg. 2014 Aug;73(2):164-9. doi: 10.1097/SAP.0b013e31829fd298. PubMed PMID: 24691338.
30) Breugom AJ, Boelens PG, van den Broek CB, Cervantes A, Van Cutsem E, Schmoll HJ, Valentini V, van de Velde CJ. Quality assurance in the treatment of colorectal cancer: the EURECCA initiative. Ann Oncol. 2014 Aug;25(8):1485-92. doi: 10.1093/annonc/mdu039. Epub 2014 Mar 26. PubMed PMID: 24671742.
31) Morganti AG, Mignogna S, Caravatta L, Deodato F, Macchia G, Plantamura NM, Massaccesi M, Picardi V, Cilla S, Valentini V. FOLFIRI-bevacizumab and concurrent low-dose radiotherapy in metastatic colorectal cancer: preliminary results of a phase I-II study. J Chemother. 2014 Dec;26(6):353-8. doi: 10.1179/1973947813Y.0000000163. Epub 2014 Jan 27. PubMed PMID: 24621170.
32) Mantini G, Alitto AR, Fionda B, Frascino V, Mattiucci GC, Balducci M, Morganti AG, Valentini V. [Radiotherapy in men with prostate cancer: indications, evolutions and integrated approaches]. Urologia. 2013 Jul-Sep;80(3):188-201. Italian. PubMed PMID: 24526595.
33) Gennaro P, Chisci G, Gabriele G, Aboh IV, Cascino F, Giovannetti F, Iannetti G, Valentini V. Management of a bulky capillary hemangioma in the parapharyngeal space with minimally invasive surgery. J Craniofac Surg. 2014;25(2):e161-3. doi: 10.1097/SCS.0000000000000461. PubMed PMID: 24481164.
34) Genovesi D, Ausili Cèfaro G, Trignani M, Vinciguerra A, Augurio A, Di Tommaso M, Perrotti F, De Paoli A, Olmi P, Valentini V, Di Nicola M. Interobserver variability of clinical target volume delineation in soft-tissue sarcomas. Cancer Radiother. 2014 Mar;18(2):89-96. doi: 10.1016/j.canrad.2013.11.011. Epub 2014 Jan 17. PubMed PMID: 24440683.
35) Tudyka V, Blomqvist L, Beets-Tan RG, Boelens PG, Valentini V, van de Velde CJ, Dieguez A, Brown G. EURECCA consensus conference highlights about colon & rectal cancer multidisciplinary management: the radiology experts review. Eur J Surg Oncol. 2014 Apr;40(4):469-75. doi: 10.1016/j.ejso.2013.10.029. Epub 2013 Dec 14. Review. PubMed PMID: 24439446.
36) Balducci M, Diletto B, Chiesa S, D'Agostino GR, Gambacorta MA, Ferro M, Colosimo C, Maira G, Anile C, Valentini V. Low-dose fractionated radiotherapy and concomitant chemotherapy for recurrent or progressive glioblastoma: final report of a pilot study. Strahlenther Onkol. 2014 Apr;190(4):370-6. doi: 10.1007/s00066-013-0506-z. Epub 2014 Jan 17. PubMed PMID: 24429479.
37) Ferrandina G, Ercoli A, Fagotti A, Fanfani F, Gallotta V, Margariti AP, Salerno MG, Chiantera V, Legge F, Macchia G, Morganti AG, Valentini V, Scambia G. Completion surgery after concomitant chemoradiation in locally advanced cervical cancer: a comprehensive analysis of pattern of postoperative complications. Ann Surg Oncol. 2014 May;21(5):1692-9. doi: 10.1245/s10434-013-3471-y. Epub 2014 Jan 10. PubMed PMID: 24407316.
38) Persiani R, Biondi A, Gambacorta MA, Bertucci Zoccali M, Vecchio FM, Tufo A, Coco C, Valentini V, Doglietto GB, D'Ugo D. Prognostic implications of the lymph node count after neoadjuvant treatment for rectal cancer. Br J Surg. 2014 Jan;101(2):133-42. doi: 10.1002/bjs.9341. PubMed PMID: 24375303.
39) de Vincentiis M, De Virgilio A, Bussu F, Gallus R, Gallo A, Bastanza G, Parrilla C, Greco A, Galli J, Turchetta R, Almadori G, Pagliuca G, Valentini V, Paludetti G. Oncologic results of the surgical salvage of recurrent laryngeal squamous cell carcinoma in a multicentric retrospective series: Emerging role of supracricoid partial laryngectomy. Head Neck. 2015 Jan;37(1):84-91. doi: 10.1002/hed.23563. Epub 2014 Apr 17. PubMed PMID: 24327466.
40) European Partnership Action Against Cancer consensus group, Borras JM, Albreht T, Audisio R, Briers E, Casali P, Esperou H, Grube B, Hamoir M, Henning G, Kelly J, Knox S, Nabal M, Pierotti M, Lombardo C, van Harten W, Poston G, Prades J, Sant M, Travado L, Valentini V, van de Velde C, van den Bogaert S, van den Bulcke M, van Hoof E, van den Neucker I, Wilson R. Policy statement on multidisciplinary cancer care. Eur J Cancer. 2014 Feb;50(3):475-80. doi: 10.1016/j.ejca.2013.11.012. Epub 2013 Dec 6. PubMed PMID: 24321260.
41) Massaccesi M, Ippolito E, Deodato F, Cilla S, Digesù C, Macchia G, Caravatta L, Picardi V, Mattiucci GC, Di Lallo A, Cuscunà D, Cellini N, Valentini V, Morganti AG. Radioprotective effect of calcium channel blockers against late rectal bleeding in prostate cancer. Radiol Med. 2014 May;119(5):343-7. doi: 10.1007/s11547-013-0346-z. Epub 2013 Dec 6. PubMed PMID: 24311192.
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43) Mattiucci GC, Autorino R, D'Agostino GR, Deodato F, Macchia G, Perri V, Tringali A, Morganti AG, Mutignani M, Valentini V. Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma. Crit Rev Oncol Hematol. 2014 Apr;90(1):58-67. doi: 10.1016/j.critrevonc.2013.10.007. Epub 2013 Nov 2. Review. PubMed PMID: 24289902.
44) Valentini V, Glimelius B, Haustermans K, Marijnen CA, Rödel C, Gambacorta MA, Boelens PG, Aristei C, van de Velde CJ. EURECCA consensus conference highlights about rectal cancer clinical management: the radiation oncologist's expert review. Radiother Oncol. 2014 Jan;110(1):195-8. doi: 10.1016/j.radonc.2013.10.024. Epub 2013 Nov 25. PubMed PMID: 24286634.
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47) Macchia G, Cilla S, Morganti AG, Deodato F, Legge F, Piermattei A, Chiantera V, Scambia G, Valentini V, Ferrandina G. Adjuvant volumetric-modulated arc therapy with simultaneous integrated boost in endometrial cancer. Planning and toxicity comparison. Acta Oncol. 2014 Feb;53(2):251-8. doi: 10.3109/0284186X.2013.819997. Epub 2013 Sep 19. PubMed PMID: 24050516.
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50) Cilla S, Digesù C, Macchia G, Deodato F, Morganti AG. Comment on "Field-in-field plan does not improve the dosimetric out come compared with the wedged beams plan for breast cancer radiotherapy" by Sun, L.-M.; et al. Med. Dosim.39:79-82; 2014. Med Dosim. 2014 Winter;39(4):285. doi: 10.1016/j.meddos.2014.05.007. Epub 2014 Jul 4. PubMed PMID: 25001060.
51) Cilla S, Digesù C, Macchia G, Deodato F, Sallustio G, Piermattei A, Morganti AG. Clinical implications of different calculation algorithms in breast radiotherapy: a comparison between pencil beam and collapsed cone convolution. Phys Med. 2014 Jun;30(4):473-81. doi: 10.1016/j.ejmp.2014.01.002. Epub 2014 Feb 1. PubMed PMID: 24491400.
52) Cilla S, Azario L, Greco F, Fidanzio A, Porcelli A, Grusio M, Macchia G, Morganti AG, Meluccio D, Piermattei A. An in-vivo dosimetry procedure for Elekta step and shoot IMRT. Phys Med. 2014 Jun;30(4):419-26. doi: 10.1016/j.ejmp.2013.11.005. Epub 2013 Dec 19. PubMed PMID: 24361278.
53) Cilla S, Deodato F, Digesù C, Macchia G, Picardi V, Ferro M, Sallustio G, De Spirito M, Piermattei A, Morganti AG. Assessing the feasibility of volumetric-modulated arc therapy using simultaneous integrated boost (SIB-VMAT): An analysis for complex head-neck, high-risk prostate and rectal cancer cases. Med Dosim. 2014 Spring;39(1):108-16. doi: 10.1016/j.meddos.2013.11.001. Epub 2013 Dec 15. PubMed PMID: 24342167.
54) Ferrandina G, Lucidi A, De Ninno M, Carbone A, Chiantera V, Morganti AG, Macchia G. Successful treatment of a young patient with locally advanced clear cell adenocarcinoma of the uterine cervix undergoing chemoradiation followed by radical surgery. Gynecol Obstet Invest. 2014;77(1):64-7. doi: 10.1159/000356685. Epub 2013 Nov 27. PubMed PMID: 24296792.
Medical Physics
1) Cilla S, Azario L, Greco F, Fidanzio A, Porcelli A, Grusio M, Macchia G, Morganti A G, Meluccio D, Piermattei A. An in-vivo dosimetry procedure for Elekta step and shoot IMRT. Physica Medica 30(4), 419-26, (2014).
2) Fidanzio A, Porcelli A, Azario L, Greco F, Cilla S, Grusio M, Balducci M, Valentini V, Piermattei A.Quasi real time in vivo dosimetry for VMAT. Physica Medica 41 (6), (2014).
